Assay Detail
Binding
CHEMBL814749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against Lactobacillus casei thymidylate synthetase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.08 | 4.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350097 | — | — | 1 | 4.11 |
| CHEMBL124631 | — | — | 1 | 4.04 |
| CHEMBL173271 | — | — | 1 | - |
| CHEMBL170101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350097 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL124631 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL173271 | — | IC50 | = | 920000.0 | nM | - |
| CHEMBL170101 | — | IC50 | > | 1000000.0 | nM | - |