Assay Detail
Binding
CHEMBL814790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding to Tachykinin receptor 1
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.96 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66635 | — | — | 1 | 9.40 |
| CHEMBL66441 | — | — | 1 | 9.22 |
| CHEMBL303803 | — | — | 1 | 9.22 |
| CHEMBL60504 | — | — | 1 | 9.15 |
| CHEMBL67171 | — | — | 1 | 9.10 |
| CHEMBL304106 | — | — | 1 | 9.10 |
| CHEMBL441252 | — | — | 1 | 9.10 |
| CHEMBL302329 | — | — | 1 | 9.10 |
| CHEMBL540651 | — | — | 1 | 9.00 |
| CHEMBL68060 | — | — | 2 | 9.00 |
| CHEMBL446146 | — | — | 1 | 9.00 |
| CHEMBL66763 | — | — | 1 | 9.00 |
| CHEMBL68234 | — | — | 1 | 8.96 |
| CHEMBL66332 | — | — | 1 | 8.89 |
| CHEMBL57993 | — | — | 1 | 8.82 |
| CHEMBL308891 | — | — | 1 | 8.70 |
| CHEMBL67508 | — | — | 1 | 8.70 |
| CHEMBL305055 | — | — | 1 | 8.52 |
| CHEMBL66106 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66635 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL66441 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL303803 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL60504 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL67171 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL304106 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL441252 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL302329 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL446146 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL68060 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL540651 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL66763 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL68234 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL68060 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL66332 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL57993 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL308891 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL67508 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL305055 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL66106 | — | Ki | = | 5.0 | nM | 8.30 |