Assay Detail
Binding
CHEMBL814834
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Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.93 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104333 | — | — | 1 | 8.30 |
| CHEMBL105438 | — | — | 1 | 7.96 |
| CHEMBL431645 | — | — | 1 | 7.92 |
| CHEMBL104279 | — | — | 1 | 7.85 |
| CHEMBL319613 | — | — | 1 | 7.85 |
| CHEMBL104519 | — | — | 1 | 7.70 |
| CHEMBL106095 | — | — | 1 | 7.57 |
| CHEMBL106226 | — | — | 1 | 7.55 |
| CHEMBL107061 | — | — | 1 | 7.50 |
| CHEMBL105427 | — | — | 1 | 7.22 |
| CHEMBL108258 | — | — | 1 | 7.01 |
| CHEMBL322368 | — | — | 1 | 7.00 |
| CHEMBL321955 | — | — | 1 | 6.89 |
| CHEMBL322152 | — | — | 1 | 6.88 |
| CHEMBL318079 | — | — | 1 | 6.84 |
| CHEMBL105061 | — | — | 1 | 6.69 |
| CHEMBL104813 | — | — | 1 | 6.56 |
| CHEMBL321976 | — | — | 1 | 6.33 |
| CHEMBL316756 | — | — | 1 | 6.21 |
| CHEMBL104691 | — | — | 1 | 6.18 |
| CHEMBL104651 | — | — | 1 | 6.17 |
| CHEMBL1788130 | — | — | 1 | 6.07 |
| CHEMBL105740 | — | — | 1 | 6.03 |
| CHEMBL104583 | — | — | 1 | 6.00 |
| CHEMBL105421 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104333 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL105438 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL431645 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL104279 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL319613 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL104519 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL106095 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL106226 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL107061 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL105427 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL108258 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL322368 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL321955 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL322152 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL318079 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL105061 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL104813 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL321976 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL316756 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL104691 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL104651 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL1788130 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL105740 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL104583 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL105421 | — | IC50 | = | 8100.0 | nM | 5.09 |