Assay Detail
Functional
CHEMBL814852
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Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Muscularis mucosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent and highly selective neurokinin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.28 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301477 | — | — | 1 | 9.40 |
| CHEMBL301841 | — | — | 1 | 9.40 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.00 |
| CHEMBL291903 | — | — | 1 | 8.57 |
| CHEMBL54622 | — | — | 1 | 8.15 |
| CHEMBL280020 | — | — | 1 | 8.08 |
| CHEMBL2372949 | — | — | 1 | 7.96 |
| CHEMBL299503 | — | — | 1 | 7.22 |
| CHEMBL2372953 | — | — | 1 | 6.73 |
| CHEMBL2372954 | — | — | 1 | - |
| CHEMBL292435 | — | — | 1 | - |
| CHEMBL293747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301477 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL301841 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL235363 | SUBSTANCE P | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL291903 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL54622 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL280020 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2372949 | — | EC50 | = | 11.1 | nM | 7.96 |
| CHEMBL299503 | — | EC50 | = | 59.7 | nM | 7.22 |
| CHEMBL2372953 | — | EC50 | = | 188.0 | nM | 6.73 |
| CHEMBL2372954 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL292435 | — | EC50 | > | 500.0 | nM | - |
| CHEMBL293747 | — | EC50 | > | 300.0 | nM | - |