Assay Detail
Functional
CHEMBL814855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 7.09 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134091 | — | — | 1 | 8.89 |
| CHEMBL217406 | NEUROKININ A | — | 1 | 8.77 |
| CHEMBL335054 | — | — | 1 | 8.52 |
| CHEMBL131872 | — | — | 1 | 8.43 |
| CHEMBL134012 | — | — | 1 | 7.82 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 7.57 |
| CHEMBL134481 | — | — | 1 | 7.48 |
| CHEMBL267712 | — | — | 1 | 7.35 |
| CHEMBL131923 | — | — | 1 | 7.23 |
| CHEMBL135186 | — | — | 1 | 7.21 |
| CHEMBL262048 | — | — | 1 | 7.04 |
| CHEMBL335248 | — | — | 1 | 7.03 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 6.78 |
| CHEMBL339391 | — | — | 1 | 6.25 |
| CHEMBL262049 | — | — | 1 | 5.92 |
| CHEMBL337465 | — | — | 1 | 5.92 |
| CHEMBL133362 | — | — | 1 | 5.86 |
| CHEMBL337037 | — | — | 1 | 5.68 |
| CHEMBL407511 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134091 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL217406 | NEUROKININ A | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL335054 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL131872 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL134012 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL437797 | NEUROKININ B | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL134481 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL267712 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL131923 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL135186 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL262048 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL335248 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL235363 | SUBSTANCE P | EC50 | = | 167.0 | nM | 6.78 |
| CHEMBL339391 | — | EC50 | = | 566.0 | nM | 6.25 |
| CHEMBL262049 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL337465 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL133362 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL337037 | — | EC50 | = | 2104.0 | nM | 5.68 |
| CHEMBL407511 | — | EC50 | = | 13000.0 | nM | 4.89 |