Assay Detail
Binding
CHEMBL814938
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In vitro thrombin inhibition
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.88 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329908 | — | — | 1 | 7.10 |
| CHEMBL94702 | — | — | 1 | 6.28 |
| CHEMBL93549 | — | — | 1 | 6.25 |
| CHEMBL175546 | — | — | 1 | 6.20 |
| CHEMBL97597 | — | — | 1 | 6.19 |
| CHEMBL51173 | — | — | 1 | 6.16 |
| CHEMBL317076 | — | — | 1 | 5.85 |
| CHEMBL316703 | — | — | 1 | 5.80 |
| CHEMBL328184 | — | — | 1 | 5.30 |
| CHEMBL419881 | — | — | 1 | 5.22 |
| CHEMBL419153 | — | — | 1 | 4.32 |
| CHEMBL315892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329908 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL94702 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL93549 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL175546 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL97597 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL51173 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL317076 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL316703 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL328184 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL419881 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL419153 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL315892 | — | IC50 | = | 209000.0 | nM | - |