Assay Detail
Binding
CHEMBL814945
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Binding affinity towards thrombin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.25 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062141 | — | — | 1 | 10.05 |
| CHEMBL416795 | — | — | 1 | 10.00 |
| CHEMBL352564 | — | — | 1 | 9.40 |
| CHEMBL434497 | — | — | 1 | 8.52 |
| CHEMBL125181 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062141 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL416795 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL352564 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL434497 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL125181 | — | Ki | = | 5.0 | nM | 8.30 |