Assay Detail
Binding
CHEMBL814946
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Binding affinity towards thrombin was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.75 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062141 | — | — | 1 | 10.05 |
| CHEMBL416795 | — | — | 1 | 10.00 |
| CHEMBL364255 | — | — | 1 | 8.82 |
| CHEMBL434417 | — | — | 1 | 8.60 |
| CHEMBL131999 | — | — | 1 | 8.60 |
| CHEMBL130119 | — | — | 1 | 8.52 |
| CHEMBL125181 | — | — | 1 | 8.31 |
| CHEMBL420689 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062141 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL416795 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL364255 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL434417 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL131999 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL130119 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL125181 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL420689 | — | Ki | = | 75.0 | nM | 7.12 |