Assay Detail
Binding
CHEMBL814972
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Inhibitory constant evaluated against thrombin (Factor IIa)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.02 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420682 | — | — | 1 | 10.34 |
| CHEMBL116202 | — | — | 1 | 10.30 |
| CHEMBL116258 | — | — | 1 | 9.89 |
| CHEMBL11157 | L-374087 | — | 1 | 9.30 |
| CHEMBL287614 | — | — | 1 | 9.30 |
| CHEMBL19080 | L-375378 | — | 1 | 9.10 |
| CHEMBL117098 | — | — | 1 | 8.48 |
| CHEMBL119820 | — | — | 1 | 8.48 |
| CHEMBL117387 | — | — | 1 | 8.39 |
| CHEMBL115643 | — | — | 1 | 8.34 |
| CHEMBL116015 | — | — | 1 | 8.28 |
| CHEMBL334257 | — | — | 1 | 8.18 |
| CHEMBL296041 | — | — | 1 | 8.15 |
| CHEMBL332934 | — | — | 1 | 7.41 |
| CHEMBL115755 | — | — | 1 | 7.31 |
| CHEMBL118077 | — | — | 1 | 7.21 |
| CHEMBL117365 | — | — | 1 | 6.89 |
| CHEMBL321130 | — | — | 1 | 6.60 |
| CHEMBL324349 | — | — | 1 | 6.50 |
| CHEMBL119779 | — | — | 1 | 6.33 |
| CHEMBL117147 | — | — | 1 | 6.31 |
| CHEMBL116597 | — | — | 1 | 5.34 |
| CHEMBL419773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420682 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL116202 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL116258 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL11157 | L-374087 | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL287614 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL19080 | L-375378 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL117098 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL119820 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL117387 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL115643 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL116015 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL334257 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL296041 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL332934 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL115755 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL118077 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL117365 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL321130 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL324349 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL119779 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL117147 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL116597 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL419773 | — | Ki | = | 0.0034 | nM | - |