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Assay Detail

CHEMBL815005

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of bovine trypsin(Trp).
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Serine protease 1 (CHEMBL3769)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors.
Guilford WJ, Shaw KJ, Dallas JL, Koovakkat S, Lee W, Liang A, Light DR, McCarrick MA, Whitlow M, Ye B, Morrissey MM.
J Med Chem (1999) 42 : 5415 -5425
PubMed 10639283 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 32 6.41 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL358918 1 7.00
CHEMBL358180 1 7.00
CHEMBL151144 1 7.00
CHEMBL348671 1 6.90
CHEMBL356630 1 6.81
CHEMBL150612 1 6.80
CHEMBL150308 1 6.77
CHEMBL150739 1 6.72
CHEMBL325022 1 6.70
CHEMBL151293 1 6.65
CHEMBL151049 1 6.58
CHEMBL48233 1 6.55
CHEMBL150309 1 6.51
CHEMBL357795 1 6.47
CHEMBL326552 1 6.39
CHEMBL151164 1 6.37
CHEMBL150277 1 6.36
CHEMBL153659 1 6.30
CHEMBL151480 1 6.30
CHEMBL150962 1 6.23
CHEMBL358910 1 6.16
CHEMBL149960 1 6.14
CHEMBL153660 1 6.08
CHEMBL345710 1 6.06
CHEMBL359275 1 5.82
CHEMBL356862 1 5.68
CHEMBL355969 1 5.66
CHEMBL150434 1 5.52
CHEMBL150547 1 -
CHEMBL150718 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL358918 Ki = 100.0 nM 7.00
CHEMBL151144 Ki = 100.0 nM 7.00
CHEMBL358180 Ki = 100.0 nM 7.00
CHEMBL348671 Ki = 125.0 nM 6.90
CHEMBL356630 Ki = 155.0 nM 6.81
CHEMBL150612 Ki = 160.0 nM 6.80
CHEMBL150308 Ki = 170.0 nM 6.77
CHEMBL150739 Ki = 190.0 nM 6.72
CHEMBL325022 Ki = 200.0 nM 6.70
CHEMBL151293 Ki = 224.0 nM 6.65
CHEMBL151049 Ki = 260.0 nM 6.58
CHEMBL48233 Ki = 280.0 nM 6.55
CHEMBL150309 Ki = 310.0 nM 6.51
CHEMBL357795 Ki = 340.0 nM 6.47
CHEMBL326552 Ki = 410.0 nM 6.39
CHEMBL151164 Ki = 430.0 nM 6.37
CHEMBL150277 Ki = 440.0 nM 6.36
CHEMBL153659 Ki = 500.0 nM 6.30
CHEMBL151480 Ki = 500.0 nM 6.30
CHEMBL150962 Ki = 590.0 nM 6.23
CHEMBL358910 Ki = 690.0 nM 6.16
CHEMBL149960 Ki = 730.0 nM 6.14
CHEMBL153660 Ki = 840.0 nM 6.08
CHEMBL345710 Ki = 880.0 nM 6.06
CHEMBL359275 Ki = 1500.0 nM 5.82
CHEMBL356862 Ki = 2100.0 nM 5.68
CHEMBL355969 Ki = 2200.0 nM 5.66
CHEMBL150434 Ki = 3000.0 nM 5.52
CHEMBL150547 Ki > 500.0 nM -
CHEMBL150718 Ki > 5000.0 nM -
CHEMBL150138 Ki > 5000.0 nM -
CHEMBL357083 Ki > 5000.0 nM -