Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL815016

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of collagen-induced thromboxane A2 production in human whole blood
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Blood
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Thromboxane-A synthase (CHEMBL1835)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and pharmacological evaluation of combined thromboxane receptor antagonist/synthase inhibitors: pyridine-containing sulphonamido acids
Campbell I, Collington E, Finch H, Hayes R, Lumley P, Mills K, Pike N, Robertson G, Watts I
Bioorg Med Chem Lett (1991) 1 : 699 -704
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.17 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL161422 1 7.70
CHEMBL348790 1 7.50
CHEMBL162641 1 7.50
CHEMBL351657 1 7.50
CHEMBL280728 RIDOGREL 2.0 1 7.50
CHEMBL162879 1 7.40
CHEMBL159447 1 7.30
CHEMBL164109 1 7.30
CHEMBL422017 1 7.30
CHEMBL159936 1 7.20
CHEMBL347812 1 7.10
CHEMBL26820 (E)-ISBOGREL 1 7.00
CHEMBL159481 1 6.70
CHEMBL159979 1 6.70
CHEMBL163276 1 6.70
CHEMBL161253 1 6.30
CHEMBL159775 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL161422 IC50 = 19.95 nM 7.70
CHEMBL348790 IC50 = 31.62 nM 7.50
CHEMBL162641 IC50 = 31.62 nM 7.50
CHEMBL351657 IC50 = 31.62 nM 7.50
CHEMBL280728 RIDOGREL IC50 = 31.62 nM 7.50
CHEMBL162879 IC50 = 39.81 nM 7.40
CHEMBL159447 IC50 = 50.12 nM 7.30
CHEMBL164109 IC50 = 50.12 nM 7.30
CHEMBL422017 IC50 = 50.12 nM 7.30
CHEMBL159936 IC50 = 63.1 nM 7.20
CHEMBL347812 IC50 = 79.43 nM 7.10
CHEMBL26820 (E)-ISBOGREL IC50 = 100.0 nM 7.00
CHEMBL159481 IC50 = 199.53 nM 6.70
CHEMBL159979 IC50 = 199.53 nM 6.70
CHEMBL163276 IC50 = 199.53 nM 6.70
CHEMBL161253 IC50 = 501.19 nM 6.30
CHEMBL159775 IC50 < 1000.0 nM -