Assay Detail
Functional
CHEMBL815034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.82 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343288 | — | — | 1 | 6.41 |
| CHEMBL140220 | — | — | 1 | 6.28 |
| CHEMBL140363 | — | — | 1 | 6.28 |
| CHEMBL140223 | — | — | 1 | 6.18 |
| CHEMBL141242 | — | — | 1 | 6.09 |
| CHEMBL141508 | — | — | 1 | 6.09 |
| CHEMBL141056 | — | — | 1 | 6.07 |
| CHEMBL337597 | — | — | 1 | 6.07 |
| CHEMBL139665 | — | — | 1 | 6.07 |
| CHEMBL141270 | — | — | 1 | 6.00 |
| CHEMBL141525 | — | — | 1 | 6.00 |
| CHEMBL140681 | — | — | 1 | 6.00 |
| CHEMBL141904 | — | — | 1 | 5.89 |
| CHEMBL139889 | — | — | 1 | 5.82 |
| CHEMBL141151 | — | — | 1 | 5.82 |
| CHEMBL414618 | — | — | 1 | 5.77 |
| CHEMBL138391 | — | — | 1 | 5.60 |
| CHEMBL139143 | — | — | 1 | 5.46 |
| CHEMBL140777 | — | — | 1 | 5.37 |
| CHEMBL140680 | — | — | 1 | 5.32 |
| CHEMBL140778 | — | — | 1 | 5.30 |
| CHEMBL140537 | — | — | 1 | 5.28 |
| CHEMBL142075 | — | — | 1 | 5.25 |
| CHEMBL141235 | — | — | 1 | 5.17 |
| CHEMBL140955 | — | — | 1 | - |
| CHEMBL141317 | — | — | 1 | - |
| CHEMBL138062 | — | — | 1 | - |
| CHEMBL141316 | — | — | 1 | - |
| CHEMBL140047 | — | — | 1 | - |
| CHEMBL141007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343288 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL140220 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL140363 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL140223 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL141242 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL141508 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL141056 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL337597 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL139665 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL141270 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL141525 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL140681 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL141904 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL139889 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL141151 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL414618 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL138391 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL139143 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL140777 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL140680 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL140778 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL140537 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL142075 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL141235 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL142088 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140818 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL142146 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139195 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL141007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140047 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL141316 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL138062 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL141317 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140955 | — | IC50 | > | 10000.0 | nM | - |