Assay Detail
Functional
CHEMBL815069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of substance P induced phosphatidyl inositol turnover in human U-373 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.42 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 8.05 |
| CHEMBL290364 | — | — | 1 | 7.92 |
| CHEMBL43912 | — | — | 1 | 7.62 |
| CHEMBL297883 | — | — | 1 | 6.82 |
| CHEMBL295122 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL290364 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL43912 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL297883 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL295122 | — | IC50 | = | 210.0 | nM | 6.68 |