Assay Detail
Functional
CHEMBL815077
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In vitro antitumor effects against human U-373MG cell lines.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro antitumor activity of phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine: structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.93 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119700 | — | — | 1 | 8.15 |
| CHEMBL117427 | — | — | 1 | 7.16 |
| CHEMBL117784 | — | — | 1 | 7.00 |
| CHEMBL118655 | — | — | 1 | 6.22 |
| CHEMBL333433 | — | — | 1 | 6.10 |
| CHEMBL325202 | — | — | 1 | 6.10 |
| CHEMBL334217 | — | — | 1 | 6.10 |
| CHEMBL331163 | — | — | 1 | 6.00 |
| CHEMBL118709 | — | — | 1 | 5.70 |
| CHEMBL117616 | — | — | 1 | 5.40 |
| CHEMBL334029 | — | — | 1 | 5.40 |
| CHEMBL119393 | — | — | 1 | 5.30 |
| CHEMBL119894 | — | — | 1 | 5.30 |
| CHEMBL331562 | — | — | 1 | 5.22 |
| CHEMBL118845 | — | — | 1 | 5.22 |
| CHEMBL118201 | — | — | 1 | 5.22 |
| CHEMBL119037 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119700 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL117427 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL117784 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL118655 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL333433 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL325202 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL334217 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL331163 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL118709 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL117616 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL334029 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL119393 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL119894 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL331562 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL118845 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL118201 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL119037 | — | IC50 | = | 6000.0 | nM | 5.22 |