Assay Detail
Functional
CHEMBL815090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 (ADA) entry into U-87 (human glioblastoma) cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U-87 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 9.22 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343520 | — | — | 1 | 9.89 |
| CHEMBL164484 | — | — | 1 | 9.82 |
| CHEMBL140552 | — | — | 1 | 9.59 |
| CHEMBL140912 | — | — | 1 | 9.55 |
| CHEMBL141683 | — | — | 1 | 9.46 |
| CHEMBL351625 | — | — | 1 | 9.44 |
| CHEMBL161664 | — | — | 1 | 9.40 |
| CHEMBL82301 | VICRIVIROC | 3.0 | 1 | 9.22 |
| CHEMBL350563 | — | — | 1 | 9.16 |
| CHEMBL140390 | — | — | 1 | 9.05 |
| CHEMBL335120 | — | — | 1 | 9.03 |
| CHEMBL349008 | — | — | 1 | 8.98 |
| CHEMBL341758 | — | — | 1 | 8.93 |
| CHEMBL162880 | — | — | 1 | 8.91 |
| CHEMBL161587 | — | — | 1 | 8.74 |
| CHEMBL141201 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343520 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL164484 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL140552 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL140912 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL141683 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL351625 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL161664 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL82301 | VICRIVIROC | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL350563 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL140390 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL335120 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL349008 | — | IC50 | = | 1.04 | nM | 8.98 |
| CHEMBL341758 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL162880 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL161587 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL141201 | — | IC50 | = | 3.8 | nM | 8.42 |