Assay Detail
Functional
CHEMBL815091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit the entry of HIV-1 reporter virus (ADA) into U-87 cells by 50%
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 8.43 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105821 | — | — | 1 | 9.70 |
| CHEMBL323172 | — | — | 1 | 9.30 |
| CHEMBL109158 | — | — | 1 | 9.30 |
| CHEMBL78535 | ANCRIVIROC | 2.0 | 1 | 9.22 |
| CHEMBL105784 | — | — | 1 | 9.22 |
| CHEMBL110757 | — | — | 1 | 9.05 |
| CHEMBL107092 | — | — | 1 | 9.00 |
| CHEMBL107154 | — | — | 1 | 9.00 |
| CHEMBL320502 | — | — | 1 | 8.96 |
| CHEMBL324643 | — | — | 1 | 8.96 |
| CHEMBL324671 | — | — | 2 | 8.92 |
| CHEMBL106533 | — | — | 1 | 8.89 |
| CHEMBL443999 | — | — | 1 | 8.85 |
| CHEMBL419735 | — | — | 1 | 8.85 |
| CHEMBL317644 | — | — | 1 | 8.77 |
| CHEMBL109008 | — | — | 1 | 8.77 |
| CHEMBL318311 | — | — | 1 | 8.74 |
| CHEMBL321413 | — | — | 1 | 8.68 |
| CHEMBL112760 | — | — | 1 | 8.55 |
| CHEMBL106767 | — | — | 1 | 8.40 |
| CHEMBL106790 | — | — | 1 | 8.36 |
| CHEMBL317476 | — | — | 1 | 8.30 |
| CHEMBL106813 | — | — | 1 | 8.29 |
| CHEMBL106098 | — | — | 1 | 8.25 |
| CHEMBL418997 | — | — | 1 | 8.24 |
| CHEMBL110730 | — | — | 1 | 8.19 |
| CHEMBL106982 | — | — | 1 | 8.15 |
| CHEMBL106406 | — | — | 1 | 8.05 |
| CHEMBL331140 | — | — | 1 | 8.04 |
| CHEMBL106468 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105821 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL323172 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL109158 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL105784 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL78535 | ANCRIVIROC | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL110757 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL107092 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL107154 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL324643 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL320502 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL324671 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL106533 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL419735 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL324671 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL443999 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL109008 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL317644 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL318311 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL321413 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL112760 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL106767 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL106790 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL317476 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL106813 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL106098 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL418997 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL110730 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL106982 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL106406 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL331140 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL106468 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL106247 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL106209 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL106299 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL106369 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL110786 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL110809 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL323454 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL110185 | — | IC50 | = | 1300.0 | nM | 5.89 |