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Assay Detail

CHEMBL815106

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tubulin polymerization. (ITP)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tubulin alpha chain (CHEMBL3658)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Xia Y, Yang ZY, Xia P, Hackl T, Hamel E, Mauger A, Wu JH, Lee KH.
J Med Chem (2001) 44 : 3932 -3936
PubMed 11689079 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.26 6.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 6.34
CHEMBL129176 1 5.50
CHEMBL47360 1 5.30
CHEMBL129585 1 4.92
CHEMBL129312 1 4.85
CHEMBL126873 1 4.62
CHEMBL127066 1 -
CHEMBL125851 1 -
CHEMBL129338 1 -
CHEMBL338626 1 -
CHEMBL277048 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 460.0 nM 6.34
CHEMBL129176 IC50 = 3200.0 nM 5.50
CHEMBL47360 IC50 = 5000.0 nM 5.30
CHEMBL129585 IC50 = 12000.0 nM 4.92
CHEMBL129312 IC50 = 14000.0 nM 4.85
CHEMBL126873 IC50 = 24000.0 nM 4.62
CHEMBL127066 IC50 > 40000.0 nM -
CHEMBL125851 IC50 > 40000.0 nM -
CHEMBL129338 IC50 > 40000.0 nM -
CHEMBL338626 IC50 > 20000.0 nM -
CHEMBL277048 IC50 > 40000.0 nM -