Assay Detail
Functional
CHEMBL815126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity to inhibit the calcium mobilization response in human U-937 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.41 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112808 | — | — | 1 | 7.27 |
| CHEMBL112737 | — | — | 1 | 7.27 |
| CHEMBL112176 | — | — | 1 | 7.22 |
| CHEMBL112338 | — | — | 1 | 7.13 |
| CHEMBL112135 | — | — | 1 | 7.11 |
| CHEMBL326909 | — | — | 1 | 6.96 |
| CHEMBL264197 | — | — | 1 | 6.96 |
| CHEMBL321261 | — | — | 1 | 6.82 |
| CHEMBL114290 | — | — | 1 | 6.82 |
| CHEMBL112018 | — | — | 1 | 6.80 |
| CHEMBL112510 | — | — | 1 | 6.62 |
| CHEMBL112804 | — | — | 1 | 6.55 |
| CHEMBL112088 | — | — | 1 | 6.54 |
| CHEMBL113167 | — | — | 1 | 6.52 |
| CHEMBL116101 | — | — | 1 | 6.47 |
| CHEMBL115362 | — | — | 1 | 6.41 |
| CHEMBL112455 | — | — | 1 | 6.34 |
| CHEMBL334267 | — | — | 1 | 6.32 |
| CHEMBL111723 | — | — | 1 | 6.26 |
| CHEMBL112310 | — | — | 1 | 6.24 |
| CHEMBL324478 | — | — | 1 | 6.09 |
| CHEMBL110797 | — | — | 1 | 6.05 |
| CHEMBL111908 | — | — | 1 | 6.03 |
| CHEMBL112544 | — | — | 1 | 6.00 |
| CHEMBL325423 | — | — | 1 | 5.97 |
| CHEMBL326192 | — | — | 1 | 5.96 |
| CHEMBL111969 | — | — | 1 | 5.89 |
| CHEMBL326779 | — | — | 1 | 5.82 |
| CHEMBL313923 | — | — | 1 | 5.48 |
| CHEMBL325615 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112808 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL112737 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL112176 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL112338 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL112135 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL326909 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL264197 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL321261 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL114290 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL112018 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL112510 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL112804 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL112088 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL113167 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL116101 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL115362 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL112455 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL334267 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL111723 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL112310 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL324478 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL110797 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL111908 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL112544 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL325423 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL326192 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL111969 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL326779 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL313923 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL325615 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL115437 | — | IC50 | = | 4000.0 | nM | 5.40 |