Compound Detail
CHEMBL112510
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COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1
Basic Information
| ChEMBL ID | CHEMBL112510 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RBPUZTZVWZKYTO-ZNTNEXAZSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
660.9
MW (Da)
8.24
ALogP
7
HBA
2
HBD
114.8
PSA (Ų)
0.06
QED
2
Ro5 Violations
19
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.62
Ki 1 meas. best 6.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| U-937 CHEMBL612794 | IC50 | 6.62 | 6.62 | 240.0 | 1 |
| Leukotriene B4 receptor 1 CHEMBL3911 | Ki | 6.21 | 6.21 | 609.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| U-937 | IC50 | = | 240.0 | nM | 6.62 | Antagonistic activity to inhibit the calcium mobilization response in human U-93... | 8230122 |
| Leukotriene B4 receptor 1 | Ki | = | 609.0 | nM | 6.21 | Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leuk... | 8230122 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8230122 | 10.1021/jm00074a013 | Leukotriene B4 receptor 1 | 1 |
| 8230122 | 10.1021/jm00074a013 | U-937 | 1 |
Data from ChEMBL 36 via Core Engine