Assay Detail
Binding
CHEMBL815149
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Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate trypsin
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.88 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141676 | — | — | 1 | 8.92 |
| CHEMBL342838 | — | — | 2 | 7.16 |
| CHEMBL344204 | — | — | 1 | 6.48 |
| CHEMBL138441 | — | — | 1 | 5.81 |
| CHEMBL342914 | — | — | 2 | 4.82 |
| CHEMBL342604 | — | — | 1 | 4.22 |
| CHEMBL141424 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141676 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL342838 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL342838 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL344204 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL138441 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL342914 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL342914 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL342604 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL141424 | — | IC50 | = | 64800.0 | nM | 4.19 |