Assay Detail
Functional
CHEMBL815199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect on the polymerization of purified bovine brain tubulin.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.68 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19531 | — | — | 1 | 5.89 |
| CHEMBL351349 | — | — | 1 | 5.89 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 5.89 |
| CHEMBL152799 | — | — | 1 | 5.85 |
| CHEMBL29086 | — | — | 1 | 5.85 |
| CHEMBL155390 | — | — | 1 | 5.85 |
| CHEMBL152450 | — | — | 1 | 5.85 |
| CHEMBL346431 | — | — | 1 | 5.85 |
| CHEMBL152446 | — | — | 1 | 5.85 |
| CHEMBL351131 | — | — | 1 | 5.85 |
| CHEMBL347323 | THIOCORNIGERINE | — | 1 | 5.82 |
| CHEMBL356376 | — | — | 1 | 5.80 |
| CHEMBL348049 | — | — | 1 | 5.80 |
| CHEMBL152356 | — | — | 1 | 5.77 |
| CHEMBL154225 | — | — | 1 | 5.77 |
| CHEMBL153439 | — | — | 1 | 5.77 |
| CHEMBL277998 | — | — | 1 | 5.70 |
| CHEMBL346002 | — | — | 1 | 5.70 |
| CHEMBL438563 | — | — | 1 | 5.70 |
| CHEMBL298240 | — | — | 1 | 5.70 |
| CHEMBL152800 | — | — | 1 | 5.68 |
| CHEMBL347182 | — | — | 1 | 5.68 |
| CHEMBL282984 | — | — | 1 | 5.68 |
| CHEMBL152280 | — | — | 1 | 5.66 |
| CHEMBL155335 | — | — | 1 | 5.64 |
| CHEMBL156889 | — | — | 1 | 5.64 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.62 |
| CHEMBL312862 | DEMECOLCINE | 2.0 | 1 | 5.62 |
| CHEMBL1081 | 3-DESMETHYLCOLCHICIN | — | 1 | 5.54 |
| CHEMBL1063 | DEACETYLCOLCHICINE | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19531 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL351349 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL152799 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL29086 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL155390 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL152450 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL346431 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL152446 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL351131 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL347323 | THIOCORNIGERINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL356376 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL348049 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL153439 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL154225 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL152356 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL298240 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL346002 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL438563 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL277998 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL152800 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL347182 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL282984 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL152280 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL155335 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL156889 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL312862 | DEMECOLCINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1081 | 3-DESMETHYLCOLCHICIN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1063 | DEACETYLCOLCHICINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL351579 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL156612 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL152554 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL153454 | — | IC50 | = | 32000.0 | nM | 4.50 |