Assay Detail
Functional
CHEMBL815338
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Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2,4-Thiazolidinediones as potent and selective human beta3 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.09 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162711 | — | — | 1 | 7.68 |
| CHEMBL424167 | — | — | 1 | 6.37 |
| CHEMBL164378 | — | — | 1 | 5.93 |
| CHEMBL161949 | — | — | 1 | 5.82 |
| CHEMBL165893 | — | — | 1 | 5.70 |
| CHEMBL163262 | — | — | 1 | 5.57 |
| CHEMBL166085 | — | — | 1 | 5.54 |
| CHEMBL32590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162711 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL424167 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL164378 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL161949 | — | EC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL165893 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL163262 | — | EC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL166085 | — | EC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL32590 | — | EC50 | = | 111000.0 | nM | - |