Assay Detail
Binding
CHEMBL815359
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Compound was evaluated for its ability to inhibit the binding of [3H]-colchicine to tubulin in competitive binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.51 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 6.16 |
| CHEMBL88059 | — | — | 1 | 6.12 |
| CHEMBL145740 | — | — | 1 | 5.60 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.60 |
| CHEMBL79720 | — | — | 1 | 4.94 |
| CHEMBL357071 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL88059 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL145740 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL107 | COLCHICINE | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL79720 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL357071 | — | Ki | = | 22000.0 | nM | 4.66 |