Assay Detail
Binding
CHEMBL815443
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Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-Methylbenzanilide derivatives as a novel class of selective V(1A) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.84 | 9.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310921 | — | — | 1 | 9.99 |
| CHEMBL307483 | — | — | 1 | 9.21 |
| CHEMBL306718 | — | — | 1 | 8.53 |
| CHEMBL77105 | — | — | 1 | 8.30 |
| CHEMBL307269 | — | — | 1 | 8.24 |
| CHEMBL75489 | — | — | 1 | 8.12 |
| CHEMBL74593 | — | — | 1 | 8.06 |
| CHEMBL1794053 | GW407323A | — | 1 | 7.11 |
| CHEMBL307487 | — | — | 1 | 6.47 |
| CHEMBL76498 | — | — | 1 | 6.31 |
| CHEMBL76763 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310921 | — | Ki | = | 0.102 | nM | 9.99 |
| CHEMBL307483 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL306718 | — | Ki | = | 2.93 | nM | 8.53 |
| CHEMBL77105 | — | Ki | = | 4.97 | nM | 8.30 |
| CHEMBL307269 | — | Ki | = | 5.71 | nM | 8.24 |
| CHEMBL75489 | — | Ki | = | 7.59 | nM | 8.12 |
| CHEMBL74593 | — | Ki | = | 8.77 | nM | 8.06 |
| CHEMBL1794053 | GW407323A | Ki | = | 78.6 | nM | 7.11 |
| CHEMBL307487 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL76498 | — | Ki | = | 491.0 | nM | 6.31 |
| CHEMBL76763 | — | Ki | = | 1140.0 | nM | 5.94 |