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Assay Detail

CHEMBL815472

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypsin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Trypsin (CHEMBL2095204)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.
Lam PY, Clark CG, Li R, Pinto DJ, Orwat MJ, Galemmo RA, Fevig JM, Teleha CA, Alexander RS, Smallwood AM, Rossi KA, Wright MR, Bai SA, He K, Luettgen JM, Wong PC, Knabb RM, Wexler RR.
J Med Chem (2003) 46 : 4405 -4418
PubMed 14521405 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.66 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37251 1 7.80
CHEMBL134736 1 6.61
CHEMBL140290 1 5.58
CHEMBL342217 1 -
CHEMBL342469 1 -
CHEMBL140349 1 -
CHEMBL139579 1 -
CHEMBL136399 1 -
CHEMBL139788 1 -
CHEMBL337781 1 -
CHEMBL139121 1 -
CHEMBL343946 1 -
CHEMBL343602 1 -
CHEMBL138813 1 -
CHEMBL138787 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37251 Ki = 16.0 nM 7.80
CHEMBL134736 Ki = 248.0 nM 6.61
CHEMBL140290 Ki = 2600.0 nM 5.58
CHEMBL342217 Ki > 1600.0 nM -
CHEMBL342469 Ki > 1600.0 nM -
CHEMBL140349 Ki > 1600.0 nM -
CHEMBL139579 Ki > 1600.0 nM -
CHEMBL136399 Ki > 1600.0 nM -
CHEMBL139788 Ki > 1600.0 nM -
CHEMBL337781 Ki > 1600.0 nM -
CHEMBL139121 Ki > 1600.0 nM -
CHEMBL343946 Ki > 1600.0 nM -
CHEMBL343602 Ki > 1600.0 nM -
CHEMBL138813 Ki > 1600.0 nM -
CHEMBL138787 Ki > 1600.0 nM -