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Compound Detail

CHEMBL343602

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Cc1cc(C(=O)Nc2ccc(-c3ccccc3S(N)(=O)=O)cc2)n(-c2cccc(C(N)=O)c2)n1

Basic Information

ChEMBL ID CHEMBL343602
Phase Preclinical
Structure Type MOL
InChI Key FJNCTNKQUBFYKT-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
4
PK Parameters
6
Publications
0
Known Names

Molecular Properties

475.5
MW (Da)
2.85
ALogP
6
HBA
3
HBD
150.2
PSA (Ų)
0.39
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H21N5O4S
MW 475.53
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness -1.88

Activity Summary

Ki 1 meas. best 7.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor X
CHEMBL244
Ki 7.72 7.72 19.0 1

Pharmacokinetic Data

Parameter Value Units Species
CL 4.667 mL.min-1.kg-1 Canis lupus familiaris
F 46.0 % Canis lupus familiaris
T1/2 3.1 hr Canis lupus familiaris
T1/2 3.9 hr Canis lupus familiaris

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Coagulation factor X Ki = 19.0 nM 7.72 Inhibitory activity against Coagulation factor X (FXa) 14521405

Literature References

PubMed DOI Target Context # Activities
14521405 10.1021/jm020578e Canis familiaris 4
14521405 10.1021/jm020578e No relevant target 2
14521405 10.1021/jm020578e Coagulation factor X 1
14521405 10.1021/jm020578e Prothrombin 1
14521405 10.1021/jm020578e Trypsin 1
14521405 10.1021/jm020578e ADMET 1

Data from ChEMBL 36 via Core Engine