Assay Detail
Binding
CHEMBL815486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The design and synthesis of novel NK1/NK2 dual antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.48 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308148 | SAREDUTANT | 3.0 | 1 | 9.30 |
| CHEMBL72930 | — | — | 1 | 8.15 |
| CHEMBL309087 | — | — | 1 | 7.68 |
| CHEMBL405129 | — | — | 1 | 7.47 |
| CHEMBL407749 | — | — | 1 | 7.47 |
| CHEMBL293432 | — | — | 1 | 6.91 |
| CHEMBL76334 | — | — | 1 | 6.45 |
| CHEMBL311387 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308148 | SAREDUTANT | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL72930 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL309087 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL405129 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL407749 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL293432 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL76334 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL311387 | — | Ki | = | 397.0 | nM | 6.40 |