Assay Detail
Binding
CHEMBL815525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Muscle tissue |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL3762) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.80 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 7.40 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.35 |
| CHEMBL3559672 | RAUWOLFIA SERPENTINA | 4.0 | 1 | 6.54 |
| CHEMBL31410 | CORYNANTHEINE | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL3559672 | RAUWOLFIA SERPENTINA | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL31410 | CORYNANTHEINE | Ki | = | 1250.0 | nM | 5.90 |