Assay Detail
Functional
CHEMBL815526
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Calcium antagonistic activity was evaluated by in vitro inhibition of [3H]nitrendipine binding on rat cerebral cortex
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.69 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350238 | — | — | 2 | 10.74 |
| CHEMBL553942 | — | — | 1 | 10.30 |
| CHEMBL30911 | — | — | 1 | 10.15 |
| CHEMBL542812 | — | — | 1 | 10.14 |
| CHEMBL554455 | — | — | 1 | 10.00 |
| CHEMBL284056 | — | — | 1 | 9.22 |
| CHEMBL554235 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350238 | — | IC50 | = | 0.018 | nM | 10.74 |
| CHEMBL553942 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL30911 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL542812 | — | IC50 | = | 0.073 | nM | 10.14 |
| CHEMBL554455 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL284056 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3350238 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL554235 | — | IC50 | = | 3.8 | nM | 8.42 |