Assay Detail
Functional
CHEMBL815546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro Thromboxane A2 (TXA2) receptor antagonism was tested by its ability to inhibit the contraction of rat aorta induced by the stable thromboxane agonist U-46,619
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[[(4-chlorophenyl)sulfonyl]-amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 10.02 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65478 | — | — | 1 | 10.80 |
| CHEMBL66194 | — | — | 1 | 10.60 |
| CHEMBL62666 | — | — | 1 | 10.60 |
| CHEMBL65780 | — | — | 1 | 10.40 |
| CHEMBL65571 | — | — | 1 | 10.20 |
| CHEMBL65167 | — | — | 1 | 10.20 |
| CHEMBL303097 | — | — | 1 | 10.10 |
| CHEMBL65175 | — | — | 1 | 10.00 |
| CHEMBL65779 | — | — | 1 | 9.70 |
| CHEMBL64971 | — | — | 1 | 9.50 |
| CHEMBL63090 | — | — | 1 | 9.40 |
| CHEMBL65121 | — | — | 1 | 8.70 |
| CHEMBL66136 | — | — | 1 | - |
| CHEMBL417742 | — | — | 1 | - |
| CHEMBL65378 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65478 | — | Kd | = | 0.01585 | nM | 10.80 |
| CHEMBL66194 | — | Kd | = | 0.02512 | nM | 10.60 |
| CHEMBL62666 | — | Kd | = | 0.02512 | nM | 10.60 |
| CHEMBL65780 | — | Kd | = | 0.03981 | nM | 10.40 |
| CHEMBL65571 | — | Kd | = | 0.0631 | nM | 10.20 |
| CHEMBL65167 | — | Kd | = | 0.0631 | nM | 10.20 |
| CHEMBL303097 | — | Kd | = | 0.07943 | nM | 10.10 |
| CHEMBL65175 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL65779 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL64971 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL63090 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL65121 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL66136 | — | Kd | = | 0.003981 | nM | - |
| CHEMBL417742 | — | Kd | = | 0.003981 | nM | - |
| CHEMBL65378 | — | Kd | = | 0.002512 | nM | - |