Assay Detail
Binding
CHEMBL815552
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Compound was evaluated for its ability to inhibit specific binding of [3H]U-46619 to Thromboxane A2/ Prostaglandin H2 receptor in guinea pig platelet membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.23 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420002 | — | — | 1 | 8.36 |
| CHEMBL302514 | — | — | 1 | 7.70 |
| CHEMBL68512 | — | — | 1 | 7.52 |
| CHEMBL70314 | — | — | 1 | 6.70 |
| CHEMBL71222 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420002 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL302514 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL68512 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL70314 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL71222 | — | IC50 | = | 1400.0 | nM | 5.85 |