Assay Detail
Functional
CHEMBL815562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of horse thromboxane A2 synthase evaluated as molar concentration required to reduce thromboxane B2 formed after incubating PGH-2 with platelet microsomes.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Equus caballus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.43 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 7.58 |
| CHEMBL92414 | — | — | 1 | 7.36 |
| CHEMBL420251 | — | — | 1 | 7.20 |
| CHEMBL91799 | — | — | 1 | 7.05 |
| CHEMBL420994 | — | — | 1 | 6.75 |
| CHEMBL82479 | — | — | 1 | 6.40 |
| CHEMBL92863 | — | — | 1 | 6.31 |
| CHEMBL92083 | — | — | 1 | 6.30 |
| CHEMBL327696 | — | — | 1 | 6.28 |
| CHEMBL89938 | — | — | 1 | 6.14 |
| CHEMBL90996 | — | — | 1 | 6.08 |
| CHEMBL92247 | — | — | 1 | 6.02 |
| CHEMBL327426 | — | — | 1 | 6.01 |
| CHEMBL93265 | — | — | 1 | 5.96 |
| CHEMBL92933 | — | — | 1 | 5.82 |
| CHEMBL328487 | — | — | 1 | 5.54 |
| CHEMBL93678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL92414 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL420251 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL91799 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL420994 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL82479 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL92863 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL92083 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL327696 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL89938 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL90996 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL92247 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL327426 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL93265 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL92933 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL328487 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL93678 | — | IC50 | = | 9e-07 | — | - |