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Assay Detail

CHEMBL815574

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonistic activity against Tachykinin receptor 3 was determined in the rat everted portal vein (RPV)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuromedin-K receptor (CHEMBL3154)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Conformational analysis of three NK1 tripeptide antagonists: a proton nuclear magnetic resonance study.
Caliendo G, Grieco P, Perissutti E, Santagada V, Saviano G, Tancredi T, Temussi PA.
J Med Chem (1997) 40 : 594 -601
PubMed 9046350 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.40 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL156186 1 5.80
CHEMBL157858 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL156186 Kd = 1584.89 nM 5.80
CHEMBL157858 Kd = 10000.0 nM 5.00