Assay Detail
ADMET
CHEMBL815584
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Inhibitory concentration required to kill 50% of the cells was evaluated under anaerobic (N2) conditions from chinese hamster V79 cells.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | V79 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cyclopropamitosenes, novel bioreductive anticancer agents. Synthesis, electrochemistry, and biological activity of 7-substituted cyclopropamitosenes and related indolequinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75198 | — | — | 1 | 8.52 |
| CHEMBL127824 | — | — | 1 | 8.30 |
| CHEMBL125922 | — | — | 1 | 7.60 |
| CHEMBL421663 | — | — | 1 | 7.22 |
| CHEMBL273801 | — | — | 1 | 7.16 |
| CHEMBL338521 | — | — | 1 | 7.00 |
| CHEMBL331961 | — | — | 1 | 6.92 |
| CHEMBL127660 | — | — | 1 | 6.85 |
| CHEMBL329249 | — | — | 1 | 6.52 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.40 |
| CHEMBL127286 | — | — | 1 | 6.35 |
| CHEMBL127971 | — | — | 1 | 6.16 |
| CHEMBL126433 | — | — | 1 | 5.96 |
| CHEMBL127947 | — | — | 1 | 5.92 |
| CHEMBL125262 | — | — | 1 | 5.70 |
| CHEMBL126446 | — | — | 1 | 5.46 |
| CHEMBL124008 | — | — | 1 | 5.40 |
| CHEMBL340713 | — | — | 1 | 5.40 |
| CHEMBL124924 | — | — | 1 | 5.00 |
| CHEMBL126455 | — | — | 1 | 4.60 |
| CHEMBL68744 | — | — | 1 | - |
| CHEMBL127996 | — | — | 1 | - |
| CHEMBL127473 | — | — | 1 | - |
| CHEMBL124990 | — | — | 1 | - |
| CHEMBL124257 | — | — | 1 | - |
| CHEMBL333887 | — | — | 1 | - |
| CHEMBL341466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75198 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL127824 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL125922 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL421663 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL273801 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL338521 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL331961 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL127660 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL329249 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL127286 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL127971 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL126433 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL127947 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL125262 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL126446 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL124008 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL340713 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL124924 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL126455 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL68744 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL127996 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL127473 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL124990 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL124257 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL333887 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL341466 | — | IC50 | = | 550000.0 | nM | - |