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Assay Detail

CHEMBL815586

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity was determined against V79 cell line in chinese hamster
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type V79
Confidence 1 — Organism
Curated By Expert

Target

V79 (CHEMBL614074)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA.
J Med Chem (2003) 46 : 5533 -5545
PubMed 14640560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.88 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37705 1 6.48
CHEMBL155391 1 6.04
CHEMBL151191 1 5.80
CHEMBL151008 1 5.77
CHEMBL275497 1 5.72
CHEMBL346169 1 5.46
CHEMBL356845 1 5.22
CHEMBL345280 1 4.70
CHEMBL152837 1 4.62
CHEMBL151905 1 4.62
CHEMBL278726 1 4.39
CHEMBL23612 1 4.37
CHEMBL347509 1 4.36
CHEMBL153152 1 4.28
CHEMBL347990 1 4.28
CHEMBL357531 1 4.26
CHEMBL152056 1 4.21
CHEMBL356820 1 4.17
CHEMBL153380 1 4.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37705 IC50 = 330.0 nM 6.48
CHEMBL155391 IC50 = 920.0 nM 6.04
CHEMBL151191 IC50 = 1600.0 nM 5.80
CHEMBL151008 IC50 = 1700.0 nM 5.77
CHEMBL275497 IC50 = 1900.0 nM 5.72
CHEMBL346169 IC50 = 3500.0 nM 5.46
CHEMBL356845 IC50 = 6000.0 nM 5.22
CHEMBL345280 IC50 = 20000.0 nM 4.70
CHEMBL152837 IC50 = 24000.0 nM 4.62
CHEMBL151905 IC50 = 24000.0 nM 4.62
CHEMBL278726 IC50 = 41000.0 nM 4.39
CHEMBL23612 IC50 = 43000.0 nM 4.37
CHEMBL347509 IC50 = 44000.0 nM 4.36
CHEMBL153152 IC50 = 53000.0 nM 4.28
CHEMBL347990 IC50 = 52000.0 nM 4.28
CHEMBL357531 IC50 = 55000.0 nM 4.26
CHEMBL152056 IC50 = 62000.0 nM 4.21
CHEMBL356820 IC50 = 68000.0 nM 4.17
CHEMBL153380 IC50 = 94000.0 nM 4.03