Assay Detail
Functional
CHEMBL815615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR and erbB2 overexpressing tumor cell proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (CHEMBL2111431) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.20 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160303 | — | — | 1 | 7.05 |
| CHEMBL155761 | — | — | 1 | 6.96 |
| CHEMBL160846 | — | — | 1 | 6.54 |
| CHEMBL422347 | — | — | 1 | 5.88 |
| CHEMBL157084 | — | — | 1 | 5.61 |
| CHEMBL269620 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160303 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL155761 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL160846 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL422347 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL157084 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL269620 | — | IC50 | = | 7400.0 | nM | 5.13 |