Assay Detail
Binding
CHEMBL815658
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Inhibition of L1210 leukemia thymidylate synthase (TS) enzyme
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.63 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 7.85 |
| CHEMBL171480 | — | — | 1 | 6.89 |
| CHEMBL138870 | — | — | 1 | 6.66 |
| CHEMBL36739 | — | — | 1 | 5.89 |
| CHEMBL139551 | — | — | 1 | 4.92 |
| CHEMBL171790 | — | — | 1 | 4.86 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 4.70 |
| CHEMBL169376 | — | — | 1 | 4.60 |
| CHEMBL354121 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL171480 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL138870 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL36739 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL139551 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL171790 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL169376 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL354121 | — | IC50 | = | 49000.0 | nM | 4.31 |