Assay Detail
Binding
CHEMBL815662
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Inhibition of partially purified thymidylate synthase (TS)
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.41 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169981 | — | — | 1 | 7.70 |
| CHEMBL434209 | — | — | 1 | 7.40 |
| CHEMBL104358 | — | — | 1 | 7.37 |
| CHEMBL104856 | — | — | 1 | 7.35 |
| CHEMBL323363 | — | — | 1 | 7.17 |
| CHEMBL323375 | — | — | 1 | 7.13 |
| CHEMBL320108 | — | — | 1 | 7.12 |
| CHEMBL105425 | — | — | 1 | 7.11 |
| CHEMBL320621 | — | — | 1 | 7.05 |
| CHEMBL307914 | — | — | 1 | 6.92 |
| CHEMBL105899 | — | — | 1 | 6.92 |
| CHEMBL320464 | — | — | 1 | 6.89 |
| CHEMBL101425 | — | — | 1 | 6.84 |
| CHEMBL321527 | — | — | 1 | 6.77 |
| CHEMBL44037 | — | — | 1 | 6.77 |
| CHEMBL105435 | — | — | 1 | 6.72 |
| CHEMBL104759 | — | — | 1 | 6.62 |
| CHEMBL104096 | — | — | 1 | 6.54 |
| CHEMBL40321 | — | — | 1 | 6.52 |
| CHEMBL102275 | — | — | 1 | 6.51 |
| CHEMBL104871 | — | — | 1 | 6.50 |
| CHEMBL323539 | — | — | 1 | 6.32 |
| CHEMBL102938 | — | — | 1 | 6.32 |
| CHEMBL323294 | — | — | 1 | 6.30 |
| CHEMBL104025 | — | — | 1 | 6.30 |
| CHEMBL104748 | — | — | 1 | 6.27 |
| CHEMBL104851 | — | — | 1 | 6.23 |
| CHEMBL105384 | — | — | 1 | 6.17 |
| CHEMBL105597 | — | — | 1 | 6.07 |
| CHEMBL320470 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169981 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL434209 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL104358 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL104856 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL323363 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL323375 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL320108 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL105425 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL320621 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL307914 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL105899 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL320464 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL101425 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL321527 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL44037 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL105435 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL104759 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL104096 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL40321 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL102275 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL104871 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL102938 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL323539 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL323294 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL104025 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL104748 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL104851 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL105384 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL105597 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL320470 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL104670 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL73971 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL319629 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL307399 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL105150 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL104624 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL104533 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL70515 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL105208 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL104267 | — | IC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL104110 | — | IC50 | = | 11720.0 | nM | 4.93 |