Assay Detail
Binding
CHEMBL815663
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In vitro inhibition of partially purified L1210 thymidylate synthase (TS).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.15 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291075 | — | — | 1 | 7.40 |
| CHEMBL434209 | — | — | 1 | 7.40 |
| CHEMBL43454 | — | — | 1 | 6.82 |
| CHEMBL41609 | — | — | 1 | 6.80 |
| CHEMBL290469 | — | — | 1 | 6.72 |
| CHEMBL44242 | — | — | 1 | 6.66 |
| CHEMBL43080 | — | — | 1 | 6.64 |
| CHEMBL42626 | — | — | 1 | 6.64 |
| CHEMBL40321 | — | — | 1 | 6.60 |
| CHEMBL44037 | — | — | 1 | 6.58 |
| CHEMBL295866 | — | — | 1 | 6.46 |
| CHEMBL44564 | — | — | 1 | 6.38 |
| CHEMBL41225 | — | — | 1 | 6.38 |
| CHEMBL418433 | — | — | 1 | 6.36 |
| CHEMBL40539 | — | — | 1 | 6.31 |
| CHEMBL42315 | — | — | 1 | 6.26 |
| CHEMBL40851 | — | — | 1 | 6.24 |
| CHEMBL290718 | — | — | 1 | 6.17 |
| CHEMBL41445 | — | — | 1 | 6.12 |
| CHEMBL410300 | — | — | 1 | 6.12 |
| CHEMBL42357 | — | — | 1 | 6.03 |
| CHEMBL434973 | — | — | 1 | 6.03 |
| CHEMBL435171 | — | — | 1 | 5.99 |
| CHEMBL41927 | — | — | 1 | 5.97 |
| CHEMBL539936 | — | — | 1 | 5.97 |
| CHEMBL40663 | — | — | 1 | 5.92 |
| CHEMBL41424 | — | — | 1 | 5.87 |
| CHEMBL289697 | — | — | 1 | 5.87 |
| CHEMBL40877 | — | — | 1 | 5.78 |
| CHEMBL40591 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291075 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL434209 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43454 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL41609 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL290469 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL44242 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL43080 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL42626 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL40321 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL44037 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL295866 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL44564 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL41225 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL418433 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL40539 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL42315 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL40851 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL290718 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL41445 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL410300 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL42357 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL434973 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL435171 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL41927 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL539936 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL40663 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL41424 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL289697 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL40877 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL40591 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL288307 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL40195 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL44127 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL40707 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL1788164 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL42865 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL40739 | — | IC50 | = | 24780.0 | nM | 4.61 |