Assay Detail
Binding
CHEMBL815672
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Evaluated for the inhibition of thymidylate synthase in permeabilised L1210 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.61 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 7.55 |
| CHEMBL22973 | — | — | 1 | 5.00 |
| CHEMBL22793 | — | — | 1 | 4.96 |
| CHEMBL279508 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL22973 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL22793 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL279508 | — | IC50 | = | 12000.0 | nM | 4.92 |