Assay Detail
Binding
CHEMBL815679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.76 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1791078 | — | — | 1 | 6.17 |
| CHEMBL96148 | — | — | 1 | 5.96 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 5.14 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1791078 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL96148 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | IC50 | > | 10000.0 | nM | - |