Assay Detail
Binding
CHEMBL815682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.19 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 7.77 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 7.37 |
| CHEMBL1791078 | — | — | 1 | 4.92 |
| CHEMBL96148 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1791078 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL96148 | — | IC50 | = | 21000.0 | nM | 4.68 |