Assay Detail
Binding
CHEMBL815718
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Inhibitory activity against human tissue-type plasminogen activator expressed as dissociation constant
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.31 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357079 | — | — | 1 | 7.46 |
| CHEMBL356007 | — | — | 1 | 6.24 |
| CHEMBL148317 | — | — | 1 | 6.02 |
| CHEMBL154985 | — | — | 1 | 6.01 |
| CHEMBL153565 | — | — | 1 | 4.64 |
| CHEMBL357067 | — | — | 1 | 4.62 |
| CHEMBL423770 | — | — | 1 | 4.48 |
| CHEMBL346222 | — | — | 1 | 4.16 |
| CHEMBL346607 | — | — | 1 | 4.16 |
| CHEMBL348266 | — | — | 1 | - |
| CHEMBL20936 | BENZAMIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357079 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL356007 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL148317 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL154985 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL153565 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL357067 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL423770 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL346222 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL346607 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL348266 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL20936 | BENZAMIDINE | Ki | = | 910000.0 | nM | - |