Compound Detail
CHEMBL153565
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL153565 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ICXHRWNWXWMBOD-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
434.5
MW (Da)
0.09
ALogP
7
HBA
4
HBD
153.6
PSA (Ų)
0.32
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 6.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Coagulation factor X CHEMBL3656 | Ki | 6.08 | 6.08 | 840.0 | 1 |
| Prothrombin CHEMBL4471 | Ki | 5.41 | 5.41 | 3900.0 | 1 |
| Serine protease 1 CHEMBL3769 | Ki | 5.24 | 5.24 | 5700.0 | 1 |
| Tissue-type plasminogen activator CHEMBL1873 | Ki | 4.64 | 4.64 | 23000.0 | 1 |
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 4.11 | 4.11 | 78000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Coagulation factor X | Ki | = | 840.0 | nM | 6.08 | Inhibitory activity against bovine coagulation factor X expressed as dissociatio... | 9876114 |
| Prothrombin | Ki | = | 3900.0 | nM | 5.41 | Inhibitory activity against bovine thrombin expressed as dissociation constant | 9876114 |
| Serine protease 1 | Ki | = | 5700.0 | nM | 5.24 | Inhibitory activity against bovine trypsin expressed as dissociation constant | 9876114 |
| Tissue-type plasminogen activator | Ki | = | 23000.0 | nM | 4.64 | Inhibitory activity against human tissue-type plasminogen activator expressed as... | 9876114 |
| Urokinase-type plasminogen activator | Ki | = | 78000.0 | nM | 4.11 | Inhibitory activity against human urokinase plasminogen activator expressed as d... | 9876114 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9876114 | 10.1021/jm981068g | Serine protease 1 | 1 |
| 9876114 | 10.1021/jm981068g | Coagulation factor X | 1 |
| 9876114 | 10.1021/jm981068g | Prothrombin | 1 |
| 9876114 | 10.1021/jm981068g | Tissue-type plasminogen activator | 1 |
| 9876114 | 10.1021/jm981068g | Urokinase-type plasminogen activator | 1 |
Data from ChEMBL 36 via Core Engine