Assay Detail
Binding
CHEMBL816561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against bovine thrombin expressed as dissociation constant
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.65 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346607 | — | — | 1 | 8.22 |
| CHEMBL97597 | — | — | 1 | 8.21 |
| CHEMBL348443 | — | — | 1 | 7.80 |
| CHEMBL347493 | — | — | 1 | 7.77 |
| CHEMBL356216 | — | — | 1 | 7.58 |
| CHEMBL422147 | — | — | 1 | 7.58 |
| CHEMBL358441 | — | — | 1 | 7.23 |
| CHEMBL104241 | — | — | 1 | 7.19 |
| CHEMBL106079 | — | — | 1 | 7.12 |
| CHEMBL153732 | — | — | 1 | 6.89 |
| CHEMBL153412 | — | — | 1 | 6.82 |
| CHEMBL357067 | — | — | 1 | 6.66 |
| CHEMBL357079 | — | — | 1 | 6.50 |
| CHEMBL348266 | — | — | 1 | 6.47 |
| CHEMBL356007 | — | — | 1 | 6.31 |
| CHEMBL319868 | — | — | 1 | 6.30 |
| CHEMBL104970 | — | — | 1 | 6.28 |
| CHEMBL148317 | — | — | 1 | 5.96 |
| CHEMBL153334 | — | — | 1 | 5.92 |
| CHEMBL423770 | — | — | 1 | 5.92 |
| CHEMBL154985 | — | — | 1 | 5.75 |
| CHEMBL153565 | — | — | 1 | 5.41 |
| CHEMBL346222 | — | — | 1 | 5.02 |
| CHEMBL358387 | — | — | 1 | 4.57 |
| CHEMBL20936 | BENZAMIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346607 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL97597 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL348443 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL347493 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL356216 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL422147 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL358441 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL104241 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL106079 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL153732 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL153412 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL357067 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL357079 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL348266 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL356007 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL319868 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL104970 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL148317 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL153334 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL423770 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL154985 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL153565 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL346222 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL358387 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL20936 | BENZAMIDINE | Ki | = | 890000.0 | nM | - |