Assay Detail
Binding
CHEMBL817634
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Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 4.83 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356007 | — | — | 1 | 6.39 |
| CHEMBL148317 | — | — | 1 | 5.85 |
| CHEMBL154985 | — | — | 1 | 5.80 |
| CHEMBL106079 | — | — | 1 | 5.70 |
| CHEMBL357079 | — | — | 1 | 5.47 |
| CHEMBL357067 | — | — | 1 | 5.35 |
| CHEMBL347493 | — | — | 1 | 5.03 |
| CHEMBL358441 | — | — | 1 | 4.80 |
| CHEMBL422147 | — | — | 1 | 4.60 |
| CHEMBL153412 | — | — | 1 | 4.58 |
| CHEMBL97597 | — | — | 1 | 4.51 |
| CHEMBL348443 | — | — | 1 | 4.47 |
| CHEMBL153732 | — | — | 1 | 4.46 |
| CHEMBL104241 | — | — | 1 | 4.42 |
| CHEMBL356216 | — | — | 1 | 4.40 |
| CHEMBL104970 | — | — | 1 | 4.39 |
| CHEMBL319868 | — | — | 1 | 4.32 |
| CHEMBL423770 | — | — | 1 | 4.31 |
| CHEMBL348266 | — | — | 1 | 4.26 |
| CHEMBL153334 | — | — | 1 | 4.25 |
| CHEMBL153565 | — | — | 1 | 4.11 |
| CHEMBL358387 | — | — | 1 | - |
| CHEMBL346607 | — | — | 1 | - |
| CHEMBL20936 | BENZAMIDINE | — | 1 | - |
| CHEMBL346222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356007 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL148317 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL154985 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL106079 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL357079 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL357067 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL347493 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL358441 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL422147 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL153412 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL97597 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL348443 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL153732 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL104241 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL356216 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL104970 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL319868 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL423770 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL348266 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL153334 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL153565 | — | Ki | = | 78000.0 | nM | 4.11 |
| CHEMBL358387 | — | Ki | = | 800000.0 | nM | - |
| CHEMBL346607 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL20936 | BENZAMIDINE | Ki | = | 180000.0 | nM | - |
| CHEMBL346222 | — | Ki | > | 1000000.0 | nM | - |