Assay Detail
Binding
CHEMBL815802
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Inhibition of human Thrombin
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.93 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324413 | — | — | 1 | 8.30 |
| CHEMBL355428 | — | — | 1 | 7.82 |
| CHEMBL169291 | — | — | 1 | 7.75 |
| CHEMBL169067 | — | — | 1 | 7.36 |
| CHEMBL256396 | — | — | 1 | 7.29 |
| CHEMBL166543 | — | — | 1 | 7.24 |
| CHEMBL355060 | — | — | 1 | 7.11 |
| CHEMBL169946 | — | — | 1 | 6.47 |
| CHEMBL168411 | — | — | 1 | 6.35 |
| CHEMBL170490 | — | — | 1 | 6.12 |
| CHEMBL168280 | — | — | 1 | 5.69 |
| CHEMBL256030 | — | — | 1 | 5.62 |
| CHEMBL352928 | — | — | 1 | - |
| CHEMBL433911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324413 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL355428 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL169291 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL169067 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL256396 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL166543 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL355060 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL169946 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL168411 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL170490 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL168280 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL256030 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL352928 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL433911 | — | IC50 | < | 1.0 | nM | - |