Assay Detail
Binding
CHEMBL815806
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In vitro inhibitory activity against hydrolysis of human alpha thrombin
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.05 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424316 | — | — | 1 | 8.70 |
| CHEMBL148208 | — | — | 1 | 8.00 |
| CHEMBL273196 | EFEGATRAN | 2.0 | 1 | 7.75 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 7.42 |
| CHEMBL356065 | — | — | 1 | 7.34 |
| CHEMBL147430 | — | — | 1 | 7.16 |
| CHEMBL63033 | — | — | 1 | 6.27 |
| CHEMBL148391 | — | — | 1 | 6.17 |
| CHEMBL344334 | — | — | 1 | 5.85 |
| CHEMBL428818 | — | — | 1 | 5.85 |
| CHEMBL136082 | — | — | 1 | 5.55 |
| CHEMBL343415 | — | — | 1 | 5.54 |
| CHEMBL145896 | — | — | 1 | 5.54 |
| CHEMBL145398 | — | — | 1 | 5.52 |
| CHEMBL421944 | — | — | 1 | 5.46 |
| CHEMBL146880 | — | — | 1 | 5.36 |
| CHEMBL356745 | — | — | 1 | 5.31 |
| CHEMBL357650 | — | — | 1 | 5.28 |
| CHEMBL435824 | — | — | 1 | 5.05 |
| CHEMBL144529 | — | — | 1 | 4.92 |
| CHEMBL144859 | — | — | 1 | 4.58 |
| CHEMBL146895 | — | — | 1 | 4.38 |
| CHEMBL144702 | — | — | 1 | - |
| CHEMBL144983 | — | — | 1 | - |
| CHEMBL341641 | — | — | 1 | - |
| CHEMBL144992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424316 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL148208 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL273196 | EFEGATRAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL356065 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL147430 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL63033 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL148391 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL344334 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL428818 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL136082 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL343415 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL145896 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL145398 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL421944 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL146880 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL356745 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL357650 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL435824 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL144529 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL144859 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL146895 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL144702 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL144983 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL341641 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL144992 | — | IC50 | > | 333000.0 | nM | - |