Assay Detail
Functional
CHEMBL815840
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Concentration required to give 50% inhibition of replication of VZV OKA in tissue culture
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.15 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147871 | — | — | 1 | 8.10 |
| CHEMBL3143173 | — | — | 1 | 8.00 |
| CHEMBL144817 | — | — | 1 | 7.82 |
| CHEMBL3143172 | — | — | 1 | 7.70 |
| CHEMBL3143170 | — | — | 1 | 7.30 |
| CHEMBL3143167 | — | — | 1 | 7.30 |
| CHEMBL3143171 | — | — | 1 | 7.05 |
| CHEMBL3143032 | — | — | 1 | 5.89 |
| CHEMBL3143169 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147871 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3143173 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL144817 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3143172 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3143170 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3143167 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3143171 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3143032 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3143169 | — | EC50 | = | 6000.0 | nM | 5.22 |