Assay Detail
Functional
CHEMBL815859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Minimal drug concentration necessary to inhibit incorporation of [3H]thymidine in U937 Leukemia cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.85 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289214 | — | — | 1 | 9.70 |
| CHEMBL288612 | — | — | 1 | 9.40 |
| CHEMBL38957 | — | — | 1 | 9.40 |
| CHEMBL39350 | — | — | 1 | 9.05 |
| CHEMBL289334 | — | — | 1 | 8.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL36926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289214 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL288612 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL38957 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL39350 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL289334 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL36926 | — | IC50 | = | 0.008 | nM | - |